The Effects of Growth Hormone and Insulin-Like Growth Factors I and II on Glutamine Metabolism by Skeletal Muscle of the Rat In Vitro

M. Parry-Billings; S. J. Bevan; E. Opara; C.-T. Liu; D. B. Dunger; E. A. Newsholme

doi:10.1055/s-2007-1002087

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 1993; 25(5): 243-245
DOI: 10.1055/s-2007-1002087

Originals Basic

The Effects of Growth Hormone and Insulin-Like Growth Factors I and II on Glutamine Metabolism by Skeletal Muscle of the Rat In Vitro

M. Parry-Billings, S. J. Bevan, E. Opara, C.-T. Liu, D. B. Dunger¹ , E. A. Newsholme

Cellular Nutrition Research Group, Department of Biochemistry, University of Oxford, Oxford, United Kingdom
¹Department of Paediatrics, University of Oxford, Oxford, United Kingdom

Abstract

PDF Download

Summary

Soleus muscle preparations of the rat were incubated in the presence of growth hormone, IGF-I or IGF-II. Growth hormone (10 and l00 ng/ml) increased, but IGF-I and IGF-II were without effect on the concentration of glutamine in soleus muscle. Growth hormone was without effect on the rate of release of glutamine from muscle. In contrast, the rate of release of glutamine was decreased in the presence of IGF-I (750 ng/ml) and increased in the presence of IGF-II (250 and 750 ng/ml). Growth hormone and the IGFs may therefore play an important role in the control of glutamine metabolism by skeletal muscle.

Key words

Glutamine - Amino Acids - Skeletal Muscle - Insulin-Like Growth Factors - Growth Hormone

PDF (287 kb)